Black Pepper Extract/Piperine

Latin Name:Piper nigrum L.
Active Ingredient:Piperine
CAS No:94-62-2
Specification:5%-98%piperine HPLC
MOQ:1kg
Lead Time:Within 7days after confirming order

Black Pepper Extract Information:

Active ingredient: Piperine
IUPAC Name: 1-[5-(1, 3-benzodioxol- 5-yl)-1-oxo-2, 4-pentadienyl]piperidine
Other Names: 5-(3, 4-methylenedioxyphenyl)-2, 4-pentadienoyl-2-piperidine piperoylpiperidine

Molecular Formula: C17H19NO3
Molecular Weight: 285.34
Molar Mass: 285.34 g mol − 1
Density: 1.193 g/cm3 

Piperine is commercially available. If desired, it may be extracted from black pepper using dichloromethane. The amount of piperine varies from 1-2% in long pepper, to 5-9% in the white and the black peppers of commerce. Further, it may be prepared by treating the solvent-free residue from an alcoholic extract of black pepper, with a solution of sodium hydroxide to remove resin (said to contain chavicine, an isomer of piperine) and solution of the washed, insoluble residue in warm alcohol, from which the alkaloid crystallizes on cooling.

Function:

1.Inhibit human CYP3A4 and P-glycoprotein, enzymes for the metabolism and transport of xenobiotics and metabolites importantly.

2.In animal studies, piperine also inhibited other enzymes  in drug metabolism importantly.

3.By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds.

4. Notably, piperine may enhance bioavailability of curcumin by 2000% in humans.

Application:

1.As pharmaceutical raw materials for arthritis, rheumatism, anti-inflammation, detumescence and so on, it is mainly used in pharmaceutical field;

2.As products effective ingredients for improving blood circulation and soothing the nerves, it is mainly used in health product industry;

3.As active ingredients of skin care products, it is mainly used in cosmetic industry.